ANGIOXCopy

• DRUGBANK - Bivalirudin
• indication:

  For treatment of heparin-induced thrombocytopenia

• pharmacology:

• mechanism:

  Inhibits the action of thrombin by binding both to its catalytic site and to its anion-binding exosite.

• toxicity:

• absorprion:

• halflife:

  25 min (in normal conditions)

• roouteelimination:

  Angiomax is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage

• volumedistribution:

• clearance:

  * 3.4 mL/min/kg [Normal renal function] * 3.4 mL/min/kg [mild renal function] * 2.7 mL/min/kg [moderate renal function] * 2.8 mL/min/kg [severe renal function] * 1 mL/min/kg [Dialysis-dependent patients]