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Plerixafor
- indication:Used in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM).
- pharmacologypharmacology:
- mechanism: Plerixafor inhibits the CXCR4 chemokine receptor and blocks binding to the marrow compartment of its cognate ligand, SDF-1alpha, which play a role in the trafficking and homing of human hematopoietic stem cells.
- toxicity:
- absorprion: Plerixafor is rapidly absorbed after subcutaneous injection (Tmax = 30-60 min).
- halflife: Terminal half-life ranges from 3 to 5 hours.
- roouteelimination: Approximately 70% of the parent drug is excreted in urine during first 24 h.
- volumedistribution: The apparent volume of distribution of plerixafor is 0.3 L/kg.
- clearance: