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Mevastatin
- indication:Not used theraputically due to its many side-effects. If used, however, it would be for treating hypercholesterolemia. It is typically used only to derive the approved drug, pravastatin.
- pharmacologypharmacology:
- mechanism: Mevastatin is a potent inhibitor of HMG-CoA reductase. Inhibiting this enzyme prevents the conversion of HMG-CoA into melevonic acid, which is an early step in cholesterol biosynthesis. There is also a subsequent decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol.
- toxicity: Side effects include those of other statins, such as myalgias, abdominal pain, nausea. It also has a higher chance of giving more severe side effects related to myotoxicity (myopathy, myositis, rhabdomyolysis), and hepatotoxicity, than other statins. Due to these major side effects and their enhanced rate of occurance, Mevastatin is not given therapeutically.
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: