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Sertindole
- indication:Used in the treatment of schizophrenia.
- pharmacologypharmacology:
- mechanism: Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.
- toxicity:
- absorprion: Orally available.
- halflife: 3 days
- roouteelimination:
- volumedistribution:
- clearance: