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interferon alpha-2b
- indication:Investigated for use/treatment in hepatitis (viral, B), hepatitis (viral, C), leukemia (myeloid), melanoma, and solid tumors.
- pharmacologypharmacology:
- mechanism: Interferon alpha-2b is believed to function in an immunomodulatory fashion to promote an innate immune system response to viral pathogens by acting upon external cellular receptors and stimulating a host of intracellular and extracellular activities. Within the infected cell, interferon alpha-2b action is thought to stimulate the induction of enzymes such as 2'5' oligoadenylate synthetase and protein kinase R (PKR), which function to cause degradation of viral RNA and inhibit protein synthesis to antagonize viral propagation. Extracellularly, interferon alpha-2b is thought to also enhance the expression of human leukocyte antigens (HLAs) and other HPV-specific antigens on the cell surface, thereby promoting recognition of the infected cells by cytotoxic T cells, natural killer cells and other cells of the innate immune response.
- toxicity:
- absorprion:
- halflife: 5.1 hours after a single dose. 6.2 hours after multiple doses.
- roouteelimination:
- volumedistribution:
- clearance: