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Gallium nitrate
- indication:For the treatment of hypercalcemia. Also intended for the treatment of non-hodgkin's lymphoma.
- pharmacologypharmacology:
- mechanism: Gallium nitrate is believed to exert a hypocalcemic effect by inhibiting calcium resorption from bone. Gallium nitrate localizes preferentially where bone resorption and remodeling is occurring, and inhibits osteoclast activity. Inhibition of resorption may occur via a reduction in increased bone turnover.
- toxicity:
- absorprion:
- halflife: Alpha: 1 hour. Beta: 24 hours, but lengthens to 72 to 115 hours with prolonged intravenous infusion.
- roouteelimination: Gallium nitrate is not metabolized either by the liver or the kidney and appears to be significantly excreted via the kidney.
- volumedistribution:
- clearance: * 0.15 L/hr/kg [cancer patients receiving daily infusion of gallium nitrate at a dose of 200 mg/m2 for 5 or 7 days]