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Silver sulfadiazine
- indication:Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
- pharmacologypharmacology:
- mechanism: Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect.
- toxicity: Acute oral toxicity (LD50) in rat is 10001 mg/kg.
- absorprion: Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: