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Lucanthone
- indication:Intended for use as a radiation sensitizer in the treatment of brain cancer.
- pharmacologypharmacology:
- mechanism: Recent data suggests that lucanthone inhibits post-radiation DNA repair in tumor cells. The ability of lucanthone to inhibit AP endonuclease and topoisomerase II probably account for the specific DNA repair inhibition in irradiated cells.
- toxicity:
- absorprion: Orally available
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: