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Lofexidine
- indication:Investigated for use/treatment in addictions and substance abuse.
- pharmacologypharmacology:
- mechanism: Lofexidine is an alpha2-adrenergic receptor agonist.
- toxicity: Lofexidine was tolerated at high dosage in singe dose toxicity studies in animals, the LD<sub>50</sub> being &gt;77 mg/kg. With repeat dosing in mice, rats and dogs symptoms related to the pharmacology of the drug (ataxia, sedation, tremor, unkempt appearance and exhaustion) appeared. Overdosage may cause hypotension, bradycardia and sedation.
- absorprion: Lofexidine is extensively absorbed and achieves peak plasma concentration at 3 hours after administration of a single dose. Bioavailability is over 90% following oral administration.
- halflife: 11 hours
- roouteelimination:
- volumedistribution:
- clearance: