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Tetrabenazine
- indication:For the symptomatical treatment of hyperkinetic movement disorder.
- pharmacologypharmacology:
- mechanism: Tetrabenazine works mainly as a VMAT-inhibitor and as such promotes the early metabolic degradation of the neurotransmitter dopamine.
- toxicity:
- absorprion:
- halflife:
- roouteelimination: After oral administration, tetrabenazine is extensively hepatically metabolized, and the metabolites are primarily renally eliminated. In a mass balance study in 6 healthy volunteers, approximately 75% of the dose was excreted in the urine and fecal recovery accounted for approximately 7-16% of the dose. Urinary excretion of α-HTBZ or β-HTBZ (the major metabolites)accounted for less than 10% of the administered dose.
- volumedistribution:
- clearance: