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Suramin
- indication:For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
- pharmacologypharmacology:
- mechanism: The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Suramin's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal.
- toxicity:
- absorprion: Poorly absorbed from the gastrointestinal tract.
- halflife: Approximately 36 to 60 days
- roouteelimination:
- volumedistribution:
- clearance: