-
Camptothecin
- indication:Investigated for the treatment of cancer.
- pharmacologypharmacology:
- mechanism: Camptothecin binds to the topoisomerase I and DNA complex (the covalent complex) resulting in a ternary complex, and thereby stabilizing it. This prevents DNA relegation and therefore causes DNA damage which results in apoptosis.
- toxicity: Acute oral toxicity (LD<sub>50</sub>) in mouse: 50.1 mg/kg
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: