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Lopinavir
- indication:Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.
- pharmacologypharmacology:
- mechanism: Lopinavir inhibits the HIV viral protease enzyme. This prevents cleavage of the gag-pol polyprotein and, therefore, improper viral assembly results. This subsequently results in non-infectious, immature viral particles.
- toxicity: Although human experience of acute overdosage with lopinavir is limited, accidental ingestion of the product by a young child could result in significant alcohol-related toxicity and could approach the potential lethal dose of alcohol.
- absorprion: Administered alone, lopinavir has insufficient bioavailability; however, like several HIV protease inhibitors, its blood levels are greatly increased by low doses of ritonavir, a potent inhibitor of cytochrome P450 3A4.
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: