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Imipenem
- indication:For the treatment of bacterial infections caused by susceptible bacteria.
- pharmacologypharmacology:
- mechanism: Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria. This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to pencillin binding proteins (PBPs). In E. coli and selected strains of P. aeruginosa, imipenem has shown to have the highest affinity to PBP-2, PBP-1a, and PBP-1b. This preferential binding to PBP-2 and PBP-1b results in the direct conversion of the individual cell to a spheroblast, which leads to rapid cell lysis and death without filament formation.
- toxicity:
- absorprion: Imipenem is not effectively absorbed from the gastrointestinal tract and therefore must be administered parenterally.
- halflife: 1 hour
- roouteelimination:
- volumedistribution:
- clearance: