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Phendimetrazine
- indication:Used in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.
- pharmacologypharmacology:
- mechanism: Phendimetrazine may act in a similar way to amphetamines in that it activates the alpha-adrenergic system to induce an appetite suppressive and metabolic increase effect.
- toxicity: Acute overdosage of phendimetrazine may manifest itself by the following signs and symptoms: unusual restlessness, confusion, belligerance, hallucinations, and panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension, or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Poisoning may result in convulsions, coma and death.
- absorprion: Peak plasma levels occur within 1 to 3 hours. Absorption is usually complete by 4 to 6 hours.
- halflife: 19-24 hours
- roouteelimination: The major route of elimination is via the kidneys where most of the drug and metabolites are excreted.
- volumedistribution:
- clearance: