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Methamphetamine
- indication:For the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity.
- pharmacologypharmacology:
- mechanism: Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). The mechanism of action involved in producing the beneficial behavioral changes seen in hyperkinetic children receiving methamphetamine is unknown.
- toxicity: Manifestations of acute overdosage with methamphetamine include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, hyperpyrexia, and rhabdomyolysis. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal poisoning usually terminates in convulsions and coma.
- absorprion: Rapidly absorbed from the gastrointestinal tract.
- halflife: The biological half-life has been reported in the range of 4 to 5 hours.
- roouteelimination: Excretion occurs primarily in the urine and is dependent on urine pH.
- volumedistribution:
- clearance: