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Gamma Hydroxybutyric Acid
- indication:Used as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
- pharmacologypharmacology:
- mechanism:
- toxicity:
- absorprion:
- halflife:
- roouteelimination: Animal studies indicate that metabolism is the major elimination pathway for sodium oxybate, producing carbon dioxide and water via the tricarboxylic acid (Krebs) cycle and secondarily by beta-oxidation. Succinic acid enters the Krebs cycle where it is metabolized to carbon dioxide and water. Fecal and renal excretion is negligible.
- volumedistribution: * 190 to 384 mL/kg
- clearance: * apparent oral cl=9.1 mL/min/kg [healthy adults receiving a single oral dose of 25 mg/kg] * 4.5 mL/min/kg [cirrhotic patients without ascites receiving a single oral dose of 25 mg/kg] * 4.1 mL/min/kg [cirrhotic patients with ascites receiving a single oral dose of 25 mg/kg]