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Ceftibuten
- indication:Used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.
- pharmacologypharmacology:
- mechanism: Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis.
- toxicity: Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.
- absorprion: Rapidly absorbed following oral administration.
- halflife:
- roouteelimination: Ceftibuten is excreted in the urine; 95% of the administered radioactivity was recovered either in urine or feces.
- volumedistribution: * 0.21 L/kg [adult subjects] * 0.5 L/kg [fasting pediatric patients]
- clearance: