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Methotrimeprazine
- indication:For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
- pharmacologypharmacology:
- mechanism: Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role.
- toxicity: Symptoms of overdose include convulsions, spastic movements, and coma.
- absorprion: Methotrimeprazine has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.
- halflife: Approximately 20 hours.
- roouteelimination:
- volumedistribution:
- clearance: