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Drospirenone
- indication:For the prevention of pregnancy in women who elect an oral contraceptive.
- pharmacologypharmacology:
- mechanism: Progestins such as drospirenone diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.
- toxicity:
- absorprion: Oral bioavailability is approximately 76%.
- halflife: 30 hours
- roouteelimination:
- volumedistribution:
- clearance: