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Cefoxitin
- indication:For the treatment of serious infections caused by susceptible strains microorganisms.
- pharmacologypharmacology:
- mechanism: The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.
- toxicity: The acute intravenous LD50 in the adult female mouse and rabbit was about 8.0 g/kg and greater than 1.0 g/kg, respectively. The acute intraperitoneal LD50 in the adult rat was greater than 10.0 g/kg.
- absorprion:
- halflife: The half-life after an intravenous dose is 41 to 59 minutes.
- roouteelimination: Approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period, resulting in high urinary concentrations. Cefoxitin passes into pleural and joint fluids and is detectable in antibacterial concentrations in bile.
- volumedistribution:
- clearance: