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Sulfacytine
- indication:Used orally in the treatment of acute urinary tract infections.
- pharmacologypharmacology:
- mechanism: Sulfacytine is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
- toxicity:
- absorprion: Well absorbed following oral administration.
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: