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Naloxone
- indication:For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol.
- pharmacologypharmacology:
- mechanism: While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.
- toxicity:
- absorprion: Well absorbed following intramuscular injection.
- halflife: 30-81 minutes
- roouteelimination:
- volumedistribution:
- clearance: