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Podofilox
- indication:For treatment of external genital warts (<i>Condyloma acuminatum</i>).
- pharmacologypharmacology:
- mechanism: The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication
- toxicity:
- absorprion: Topical application of 0.05 mL of 0.5% podofilox solution to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5 mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application.
- halflife: 1.0 to 4.5 hours.
- roouteelimination:
- volumedistribution:
- clearance: