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Doxepin
- indication:For the treatment of psychoneurotic patients with depression and/or anxiety
- pharmacologypharmacology:
- mechanism: The mechanism of action of doxepin is not completely understood. It is thought that Like amitriptyline, doxepin enhances the actions of norepinephrine and serotonin by blocking their reuptake at the neuronal membrane. Doxepin may also act on histamine H<sub>1</sub>-receptors, resulting in sedative effects, and beta-adrenergic receptors.
- toxicity: LD<sub>50</sub>=26 (mg/kg) (in mice, iv); LD<sub>50</sub>=16 (mg/kg) (in rats, iv); Cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity.
- absorprion: well absorbed from the gut
- halflife: 6 - 8 hours
- roouteelimination:
- volumedistribution:
- clearance: