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Cephapirin
- indication:For treatment of infections caused by susceptible bacteria.
- pharmacologypharmacology:
- mechanism: The bactericidal activity of cephapirin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
- toxicity: Rats exposed via the oral route to cephapirin displayed low acute toxicity (LD<sub>50</sub> = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects.
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: