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Pimozide
- indication:Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment.
- pharmacologypharmacology:
- mechanism: The ability of pimozide to suppress motor and phonic tics in Tourette's Disorder is thought to be primarily a function of its dopaminergic blocking activity. Pimozide binds and inhibits the dopamine D2 receptor in the CNS.
- toxicity: LD<sub>50</sub> = 1100 mg/kg (rat, oral), 228 mg/kg (mouse, oral)
- absorprion: Greater than 50% absorption after oral administration. Serum peak appears 6-8 hours post ingestion.
- halflife: 29 &plusmn; 10 hours (single-dose study of healthy volunteers).
- roouteelimination:
- volumedistribution:
- clearance: