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Pentolinium
- indication:Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
- pharmacologypharmacology:
- mechanism: Pentolinium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
- toxicity: Oral, mouse: LD<sub>50</sub> = 512 mg/kg; Oral, rat: LD<sub>50</sub> = 890 mg/kg.
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: