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Hexafluronium
- indication:Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
- pharmacologypharmacology:
- mechanism: Hexafluronium bromide is a non-competitive reversible inhibitor of human plasma cholinesterase or pseudocholinesterase. Hexafluornium probably binds to anionic side receptors near the active center, causing a conformational change in the enzyme, preventing acylation of the esteratic site. The esteratic site on cholistereases is where acetylcholine is hydrolyzed to acetic acid and choline.
- toxicity: LD<sub>50</sub> = 280 mg/kg (mouse, oral)
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: