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Almotriptan
- indication:For the treatment of acute migraine headache in adults
- pharmacologypharmacology:
- mechanism: Almotriptan binds with high affinity to human 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> receptors leading to cranial blood vessel constriction.
- toxicity:
- absorprion:
- halflife: 3-4 hours
- roouteelimination: Almotriptan is eliminated primarily by renal excretion (about 75% of the oral dose), with approximately 40% of an administered dose excreted unchanged in urine. Approximately 13% of the administered dose is excreted via feces, both unchanged and metabolized.
- volumedistribution: * 180 to 200 L
- clearance: * 57 L/h [healthy] * 34.2 L/h [moderate renal impairment (creatinine clearance between 31 and 71 mL/min)] * 9.8 L/h [severe renal impairment (creatinine clearance between 10 and 30 mL/min)]