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Remifentanil
- indication:For use during the induction and maintenance of general anesthesia.
- pharmacologypharmacology:
- mechanism: Remifentanil is a µ-opioid agonist with rapid onset and peak effect, and short duration of action. The µ-opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone.
- toxicity:
- absorprion:
- halflife: 1-20 minutes
- roouteelimination: Remifentanil is an esterase-metabolized opioid. The carboxylic acid metabolite is essentially inactive (1/4600 as potent as remifentanil in dogs) and is excreted by the kidneys with an elimination half-life of approximately 90 minutes.
- volumedistribution: * 350 mL/kg * 452 ± 144 mL/kg [neonates] * 223 ± 30.6 mL/kg [adolescents]
- clearance: * 40 mL/min/kg [young, healthy adults]