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Pemirolast
- indication:For the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis
- pharmacologypharmacology:
- mechanism: Pemirolast binds to the histamine H<sub>1</sub> receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Pemirolast has also been observed to inhibit antigen-stimulated calcium ion influx into mast cells through the blockage of calcium channels. Pemirolast inhibits the chemotaxis of eosinophils into ocular tissue, and prevents inflammatory mediator release from human eosinophils.
- toxicity:
- absorprion:
- halflife: 4.5 hours (Ophthalmic)
- roouteelimination: Following topical administration, about 10-15% of the dose was excreted unchanged in the urine.
- volumedistribution:
- clearance: