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Dromostanolone
- indication:For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
- pharmacologypharmacology:
- mechanism: Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
- toxicity: Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
- absorprion: Well absorbed following parenteral administration.
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: