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Dobutamine
- indication:For inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures
- pharmacologypharmacology:
- mechanism: Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output.
- toxicity:
- absorprion:
- halflife: 2 minutes
- roouteelimination: In human urine, the major excretion products are the conjugates of dobutamine and 3-O-methyl dobutamine.
- volumedistribution:
- clearance: