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Trifluoperazine
- indication:For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
- pharmacologypharmacology:
- mechanism: Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
- toxicity: Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: