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Esomeprazole
- indication:For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
- pharmacologypharmacology:
- mechanism: Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H<sup>+</sup>/K<sup>+</sup>-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
- toxicity: Blurred vision, confusion, drowsiness, dry mouthflushingheadache, nausea, rapid heartbeat, sweating
- absorprion: 90%
- halflife: 1-1.5 hours
- roouteelimination: Esomeprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system. Esomeprazole is excreted as metabolites primarily in urine but also in feces. Less than 1% of parent drug is excreted in the urine.
- volumedistribution: * 16 L [healthy volunteers]
- clearance: