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Tizanidine
- indication:For the management of increased muscle tone associated with spasticity
- pharmacologypharmacology:
- mechanism: Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites.
- toxicity:
- absorprion:
- halflife: 2.5 hours
- roouteelimination: Approximately 95% of an administered dose is metabolized.
- volumedistribution: * 2.4 L/kg
- clearance: