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Trimethobenzamide
- indication:For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
- pharmacologypharmacology:
- mechanism: The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.
- toxicity: Oral LD<sub>50</sub> in mice is 1600 mg/kg.
- absorprion: The relative bioavailability of the capsule formulation compared to the solution is 100%.
- halflife: The mean elimination half-life of trimethobenzamide is 7 to 9 hours.
- roouteelimination: Between 30 – 50% of a single dose in humans is excreted unchanged in the urine within 48–72 hours.
- volumedistribution:
- clearance: