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Mitotane
- indication:For treatment of inoperable adrenocortical tumours; Cushing's syndrome
- pharmacologypharmacology:
- mechanism: Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.
- toxicity:
- absorprion: About 40% oral Lysodren is absorbed
- halflife: 18-159 days
- roouteelimination: A variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues.
- volumedistribution:
- clearance: