-
Guanabenz
- indication:For management of High blood pressure
- pharmacologypharmacology:
- mechanism: Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance.
- toxicity: Excessive contraction of the pupils, irritability, low blood pressure, sleepiness, slow heartbeat, sluggishness
- absorprion: Approximately 75% absorbed from gastrointestinal tract
- halflife: 6 hours.
- roouteelimination:
- volumedistribution:
- clearance: