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Cinalukast
- indication:For Protection against second- phase inflamation in exercise-induced bronchoconstriction and Asthma.
- pharmacologypharmacology:
- mechanism: Binds to the cysteinyl leukotriene receptor. The cysteinyl leukotrienes (LTC4, LTD<sub>4</sub>, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene receptors (CysLT) found in the human airway. Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.
- toxicity:
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: