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Lactulose
- indication:For the treatment of constipation and hepatic encephalopathy.
- pharmacologypharmacology:
- mechanism: Lactulose is a synthetic sugar used in the treatment of constipation and liver disease. It consists of the monosaccharides fructose and galactose. In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of via evolved-beta galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. This in turn causes an increase in stool water content and softens the stool. In treating heptic diseases (hepatic encephalopathy) it is thought that lactulose draws out ammonia from the body in the same way that it draws out water into the colon.
- toxicity: LD<sub>50</sub>=18.2 g/kg (oral, rat). Side effects include diarrhea and resultant dehydration.
- absorprion: Poorly absorbed from the gastrointestinal tract as no human enzyme that is capable of hydrolysis of this disaccharide is present in human gastrointestinal tissue.
- halflife: 1.7-2 hours
- roouteelimination: The primary route of elimination is fecal. Urinary excretion has been determined to be 3% or less and is essentially complete within 24 hours.
- volumedistribution:
- clearance: