-
Methoxsalen
- indication:For the treatment of psoriasis and vitiligo
- pharmacologypharmacology:
- mechanism: After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
- toxicity:
- absorprion:
- halflife: Approximately 2 hours
- roouteelimination: In both mice and man, methoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours (Pathak et al. 1977).
- volumedistribution:
- clearance: