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Anisotropine Methylbromide
- indication:For use in conjunction with antacids or histamine H<sub>2</sub>-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying.
- pharmacologypharmacology:
- mechanism: Quaternary ammonium compounds such as anisotropine methylbromide inhibit the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands.
- toxicity:
- absorprion: Gastrointestinal absorption is poor and irregular. Total absorption after an oral dose is about 10 to 25%.
- halflife: Not Known
- roouteelimination:
- volumedistribution:
- clearance: