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Levallorphan
- indication:For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
- pharmacologypharmacology:
- mechanism: Levallorphan antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3.
- toxicity: Oral, rat LD<sub>50</sub>: 109&plusmn;4 mg/kg
- absorprion: Rapidly absorbed.
- halflife: 1 hour
- roouteelimination:
- volumedistribution:
- clearance: