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Cimetidine
- indication:For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
- pharmacologypharmacology:
- mechanism: Cimetidine binds to an H<sub>2</sub>-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
- toxicity: Symptoms of overdose include nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
- absorprion: Rapid 60-70%
- halflife: 2 hours
- roouteelimination: The principal route of excretion of cimetidine is the urine.
- volumedistribution:
- clearance: