-
Nitric Oxide
- indication:For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
- pharmacologypharmacology:
- mechanism: Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.
- toxicity:
- absorprion: Nitric oxide is absorbed systemically after inhalation.
- halflife: 2–6 seconds
- roouteelimination: Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled.
- volumedistribution:
- clearance: