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Zolpidem
- indication:For the short-term treatment of insomnia.
- pharmacologypharmacology:
- mechanism: Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABA<sub>A</sub> receptor chloride channel macromolecular complex. Unlike the benzodiazepines, which non-selectively interact with all three alpha-receptor subtypes, Zolpidem preferentially binds to the alpha-1 receptor.
- toxicity: Oral (male rat) LD<sub>50</sub> = 695 mg/kg. Symptoms of overdose include impairment of consciousness ranging from somnolence to light coma.
- absorprion: Zolpidem is rapidly absorbed from the GI tract.
- halflife: 2.6 hours
- roouteelimination: Zolpidem tartrate tablets are converted to inactive metabolites that are eliminated primarily by renal excretion.
- volumedistribution:
- clearance: