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Dydrogesterone
- indication:Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
- pharmacologypharmacology:
- mechanism: Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.
- toxicity: No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route.
- absorprion: Rapidly absorbed in the gastrointestinal tract with a bioavailability of 28%.
- halflife: Dydrogesterone: 5-7 hours, 20-dihydrodydrogesterone (DHD) metabolite: 14-17 hours
- roouteelimination:
- volumedistribution:
- clearance: