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Norepinephrine
- indication:Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- pharmacologypharmacology:
- mechanism: Norepinephrine functions as a peripheral vasoconstrictor (alpha-adrenergic action) and as an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action).
- toxicity: In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
- absorprion:
- halflife:
- roouteelimination:
- volumedistribution:
- clearance: